Manioc : Portail | resultats 1 - 20 pour la recherche: Bonneville, Jean-François

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

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Almanach de la Guadeloupe et dépendances pour l'année commune 1829 suivi de notices statistiques sur la Guadeloupe et Dépendances
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Statistique générale et particulière de la France et de ses colonies avec une nouvelle description topographique, physique, agricole, politique, industrielle et commerciale T.7
Auteur(s) : Herbin de Halle, Pierre Etienne (1772-18..) Peuchet, Jacques (1758-1830)
Auteurs secondaires : Poirson, Jean-Baptiste (1760-1831) Tardieu, Jean Baptiste Pierre (1746-1816)
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Histoire générale des Antilles Tome premier de la première série
Auteur(s) : Dessalles, Adrien (1809-1870)
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Auteur(s) : Malte-Brun, Conrad (1775-1826)
Auteurs secondaires : Malte-Brun, Victor-Adolphe (1816-1889)
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Exposition universelle de 1900 : colonies et Pays de Protectorat
Auteur(s) : Charles-Roux, Jules (1841-1918)
Auteurs secondaires : Landes, Gaston Célestin Th. Fabre, E.
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Auteur(s) : Rennard, Joseph (18..-1958 ; Abbé)
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